NEW PERSPECTIVES OF GENE THERAPY ON POLYGLUTAMINE SPINOCEREBELLAR ATAXIAS: FROM MOLECULAR TARGETS TO NOVEL NANOVECTORS

New Perspectives of Gene Therapy on Polyglutamine Spinocerebellar Ataxias: From Molecular Targets to Novel Nanovectors

Seven of the most frequent spinocerebellar ataxias (SCAs) are caused by a pathological expansion of a cytosine, adenine and guanine (CAG) trinucleotide repeat located in exonic regions of unrelated genes, General Purpose saddle which in turn leads to the synthesis of polyglutamine (polyQ) proteins.PolyQ proteins are prone to aggregate and form intr

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Epidemiology and Impact of Anti-Pneumococcal Vaccination and COVID-19 on Resistance of Streptococcus pneumoniae Causing Invasive Disease in Piedmont, Italy

Background: The international surveillance of antimicrobial resistance (AMR) reports S.pneumoniae as one of leading causes of death associated with AMR.Against invasive disease, several vaccinations are available and a reduction in AMR in S.pneumoniae has been observed.Here, we evaluated the impact of anti-pneumococcal vaccination policy and the SA

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Acute Effect of Kettlebell Swings on Sprint Performance

Previous research has shown that kettlebell swings (KBS), utilizing the hip-hinge technique, exhibit similar lower-limb muscle activation patterns to sprint running.This study investigated whether the inclusion of KBS in the warm-up enhances sprint performance.Moderately trained males (n = 12) and females (n = 8) performed KBS and a control (CON) c

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Continuous glucose monitoring reveals similar glycemic variability in individuals with obesity despite increased HOMA-IR

Background/aimsContinuous glucose monitoring is a well-tolerated and versatile tool for management of diabetes and metabolic disease.While its use appears to be feasible to monitor glycemic profiles in diabetics, there is a paucity of data in individuals with obesity and normal glucose tolerance.The aim of this study is to investigate glucose fluct

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